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All compounds showed good inhibitory activity at a nanomolar level and most compounds exhibited selectivity towards cox-2 inhibition.
Due to its planar conjugated ring structure, pyrazole is an.
Pyrazole is an organic heterocyclic compound characterised by a 5-membered ring containing three carbon atoms and two adjacent nitrogen atoms with the formula c 3 h 4 n 2.
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Synthesis, portrayal and natural studies of 5 membered nitrogen heterocycles page 90 pyrazoles and it is derivatives, a class of well-known.
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New pyrazole derivatives 2-5 were synthesized and evaluated for their cyclooxygenase-1 and cox-2 restrictive activity in vitro.
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One of the nitrogen atoms is neutral fashionable nature, and the other is basic.
Compounds 2a, 3b, 4a, 5b and 5e exhibited ic 5.
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N arylation of pyrazole synthesis.
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